Reaction of alpha-thiocyano car



action between an alpha-thiocyano carbonyl alpha-'thiocyano carbonyl compoundand a pri- 'ried out in an initially anhydrous medium and the reaction is removed, proceeds in such a mancyano group with migration of the remaining hywhere R1 andRarepresent the non-reactive resi- Patented Jan. 27, 1953 A 2,626,949 UNITED STATES PATENT OFFICE REACTION OF ALPHA-THIOCYANO CAR- BONYL COMPOUNDS WITH PRIMARY AMINES AND THEIR ACID SALTS James T. Gregory, Akron, Ohio, assignor to The B. F. Goodrich Company, New York, N. Y., a. corporation of New York No Drawing. Application October 31, 1950, Serial No. 193,281

9 Claims. (Cl. 260-306.7) 1 2 This invention relates to a novel chemical rerepresents the organic radical attached "to the amino group of the primary amine. Generally R1 and'Rz are hydrogen or hydrocarbon radicals containing from 1 to 10 carbon atomsand Ra compound and a primary amine or acid salt thereof and is especially concerned with the synthesis, by this reaction, of 2-imino-4-thiazo- 5 the radical attached to the amino group of a lines and their acid salts, particularly certain primary monoamine containing 1 to carbon novel compounds of this class having considerable atoms. utility for diverse purposes including their use as 'It is generally preferable in carrying out the accelerators and activators for the vlucanization reaction to employ an acid salt of "the amine of natural and synthetic rubbers. 10 since this results in formation of the'correspond- I have discovered that the reaction between an ing'acid salt of the 2-imino-4-thi'azoline which is generally insoluble in the anhydrous reaction medium and is easily recovered therefrom in excellent yield. The latter is then easily-converted under conditions such that the Water formed by quantitatively to the free imino thiazoline base by neutralization. The hydrochloride of the amine-is the preferred acid salt,but other hydromary amine oran acid salt thereof, when carner as to produce a 2-imino-4-thiazoline. The

reaction first involves the splitting out of Water halides such as the hydrobromide or hydroiodide,

between the hydroxyl group of the enol form of I and still other acid salts of the amine such as the alphathlocyano carbonyland one ofthe hythose form'edwith sulfuric, phosphoricand' other drogen atoms of the-amino group of the primary mineral acids may also be used.

amine with formation of an unstable intermediate When the free amineis used in the reaction compound (which I refer to as a thiocyano-anil the free 2-imino-4 thiazoline base which forms when the amine is aniline or similar aromatic is difiicult to isolate'because of its solubility amine, or with respect to any primary amine as a the reaction'mixture and because of the fact that thiocyano-amine) in which the nitrogenatom it rearranges easily when heated to give the of the amino group of the amine is attached to tautomeric, more-stable, 2-amino thiazo lez the carbon atom originally present in the car- (B) bonyl group of the carbonyl compound. This intermediate then undergoes ring closure between 30 the aminonitrogen and the carbon of the thio- C=NH -2 -O'N'-R; a

drogen of the amino group to the thiocyano nitrogen atom, with the result that there isformed a Z-imino-4-thiazoline containing the structure 5 Consequently, y a io of the reaction mix- I ture resulting from the reaction of this invention,

2 imino-i-thiazollne when using a free amine,-it is possible to recover "4 3 \C=NH a Z-amino thiazole. There is definite evidence to 5 S /2 indicate, however, that the latter is obtained by 40 tautomerization of the 2-imino-4-thiazoline Represented structurally the reaction proceeds rather than by direct reaction between the thioas follows: cyano carbonyl and the amine. If formedin the Alpha-Thlocyano Enol'Form Primary Intermediate Carbonyl Amine Bq-C-w G NH 'R -G-S 2-imino-4-thiazoline latter way, by simultaneous splitting. out of water due of the alpha-thiocyano carbonyl and R3 and ringcclosure the additionofaqueoushydrochloric acid to the anhydrous reaction mixture immediately after removal of water should give the hydrochloride of the 2-amino thiazole. Actually this is not the case; instead the addition of aqueous acid immediately after water removal results in recovery of the hydrochloride of the original amine indicating that the unstable intermediate represented in Equation A has been split by the water and that ring closure has not yet occurred.

As mentioned hereinabove the reaction of this invention occurs when the initial reactants are substantially anhydrous and when the water formed by the reaction is removed. A convenient method of insuring that these conditions are maintained consists in forming a mixture consisting of the thiocyano carbonyl, the primary amine or its hydrochloride, and a substantially anhydrous organic diluent which forms an azeotropic mixture with water, and then refluxing the mixture with azeotropic removal of water as formed. This, of course, also affords a convenient method for following the progress of the reaction since the amount of water removed is an index of the degree to which the reaction has occurred. Suitable organic diluents which form azeotropic mixtures with water boiling in the range of 50 to 100 (3., a desired temperature range for conducting the reaction, include benezene, isoamyl alcohol, n-butyl alcohol, isobutyl alcohol, sec. butyl alcohol, toluene, amyl alcohol, tert. butyl alcohol, ethyl acetate, methyl ethyl ketone, isopropyl alcohol, propyl alcohol, as well as mixtures of ethanol and carbon tetrachloride, trichloroethylene and ethanol, trichoroethylene and allyl alcohol, trichloroethylene and n-propyl alcohol, ethanol and ethyl acetate, ethanol and benzene, butanol and benzene, allyl alcohol and benzene, n-propyl alcohol and benzene, benzene and heptene, and the like.

However, it is not essential that any diluent be used since heating of the anhydrous reactants alone in an open vessel at a temperature such that the vapor pressure of water is suflicient to effect its removal, as at 50 to 100 0., results in occurrence of the reaction described.

Any enolizable alpha-thiocyano carbonyl compound may be employed as one of the reactants in this invention. Such a compound will, of course, contain in the keto form, the structure and will have only the one oxygen atom attached wherein R1 and R2 are hydrogen or hydrocarbon groups; however, R1 and R2 may also be radicals containing elements other than carbon and hydrogen present in non-reactive structure, as, for

example, halogen replacing hydrogen in hydrocarbongroups, oxygen in ether linkages, sulfur in thioether linkages, nitrogen and oxygen in nitro '4 groups, etc. All such alpha-thiocyano aldehydes and ketones are known types of compounds and can be readily prepared by known methods, for example, by the reaction of sodium thiocyanate with alpha-halo aldehydes and ketones.

As examples of enolizable alpha-thiocyano carbonyl compounds which are suitable reactants for the process of this invention, there may be mentioned such alpha-thiocyano-aldehydes as thiocyano-acetaldehyde, alpha-thiocyano-n-propionaldehyde, alpha thiocyano n butyraldehyde, alpha thiocyano n valeraldehyde, alpha-iso propyl alpha thiocyano acetaldehyde, alphabenzyl alpha thiocyano acetaldehyde, alphaphenyl alpha thiocyano acetaldehyde, alphanaphthyl alpha thiocyano acetaldehyde, alpha -cy clohexyl alpha thiocyano acetaldehyde, alpha chloro alpha thiocyano acetaldehyde, alpha-thiocyano-alpha-ethoxy acetaldehyde, alpha-thiocyano-beta-chlorobutyraldehyde, and alpha-thiocyano-beta-ethoxy butyraldehyde; and such alpha-thiocyano ketones as for example 3-thiocyano-propanone-2; 3-thiocyanobutanone-2; 3-thiocyano-pentanone-2; 3-thiocyano-hexanone-2; 3-thiocyano-heptanone-2; 3- phenyl 3 thiocyano propanone 2; 3 cyclohexyl 3 thiocyano propanone 2; 4 phenyl- 3-thiocyano-butanone-2; 5-phenyl-3-thiocyanopentanone-2; G-phenyl-B-thiocyano-hexanone- 2; 3-naphthyl-3-thiocyano-propanone-2; 5-ptolyl-3-thiocyano-pentanone-2 3 thiocyano-4- pentanone-2,4-thiocyano-pentanone-3; 5 thiocyano hexanone 4; 6 thiocyano hexanone- 5; phenyl l-thiocyano-ethyl ketone; 1-phenyl-3- thiocyano-butanone-Z; l-phenyl 4 thiocyanopentanone-3; naphthyl l-thiocyano-ethyl ketone; 4 thiocyano hexanone 3; 3-thiocyanoheptanone 4; 2 thiocyano octanone 3; phenyl 1 thiocyano butyl ketone; 1 phenyl 3 thiocyano-pentanone 2; 1 phenyl 4 thiocyano hexanone 3 naphthyl 1 thiocyanobutyl ketone; 5 thiocyano 1 heptenone 4; 3 cyclohexyl 3 thiocyano propanone 2; cyclohexyl 1 thiocyano ethyl ketone; cyclohexyl 1 thiocyano propyl ketone; 1 chloro 3 thiocyanobutanone 2; 1 bromo 3 thiocyanobutanone 2; 1,1 dichloro 3 thiocyanobutanone 2; 1,4 dibromo 3 thiocyanobutanone 2; 1 methoxy 3 thiocyanobutanone 2; 1- (methyl-thio) 3 thiocyanobutanone 2; 3 thiocyano 4 isopropoxy butanone 2; 3 thiocyano 4 (isopropyl thio) butanone 2; 3 thiocyano 4 ethoxy butanone 2; 3 thiocyano 4 (ethyl thio) butanone 2; 2 thiocyano 1 o nitrophenyl butanone 3; 3 thiocyano 5 chloro hexanone 2; 2 thiocyano 1,5 diphenyl 6 nitrohexanone 3; 4 thiocyano 6 butoxy 5 methylhexanone 3; 4 thiocyano 1 ethoxy 5 methylhexanone 3; 2 thiocyano cyclopentanone; 2 thiocyano cyclohexanone; 2,5 di(thiocyano) 1,4 cyclohexanedione; 2,3 di(thiocyano) 1,4 cyclohexanedione; 1,5 di(thiocyano) 2,4 pentanedione; 3,8 di(thiocyano) 4,7 decanedione; 2 (alpha thiocyanoacetonyl) cyclohexanone and 2 (alpha thiocyano acetonyl) 6 thiocyanocyclohexanone.

Although any enolizable alpha-thiocyano carbonyl compound containing the structure hereinbeforeset forth can be employed as a reactant according to the process of this invention, alphathiocyano ketones, where R1 in the general formula hereinbefore appearing is a hydrocarbon group, are preferred as reactants because at present they are more readily available.

ph'enethyram'ine, and nap'hthylenemethyl amines aminocyclohexanol,

"l-amino-s-heptanol, 2-amino-1-phenyl .octanol,

The-primary amine zemployedas-ithe :otheriwreactantthis invention either .1 as such :or, more preferably as noted above :Linithe form .of ran acid salt, can be any of itherwide variety Of primary amines available to thefa'rt. .Although unsubstituted primary amines (.tliati.is,z'aminesfcomrposed exclusively of amino groups-"attached to hydrocarbon structure as in the :case ofprimary amines of the structure '1R3NH2 where Ri is Phydro'carbon) are ordinarily employed because 'of v "their 'lower 'cost, it will 'bexunderstoocl that prifamine, 3-pheny1 sec. buty1 amine, amyl amines,

jhexyl amines, heptyl amines, ally'l amine, 2- .25 methyl allyl amine, 3-phenyl a11yl amine (cinnamylamine), cyclohexyl amine, cyclopentyl amine, aniline, toluidines, xylidines, mesidine, bisphenylamines, naphthy'l amines, benzyl'amine, 3

0 as well as substituted amines such as'Z-furanamine, 2-p-dioxanamine, B-gamma-pyranylamine, Z-aminopyridine, 4-aminopyridine, Z-aminothiazole, 2-amino alpha-methyl 4 phenyl-fi-thiazole acetic acid, 2eamino-4-p-tolyl-5-thiazole acetic acid, 3thiophenine, 4-'(aminobutyl) -piperidine, 4-( aminobutyl) pyridine, 2,2-diethoxy ethylamine, .B-benzyloxy propylamine, 3-butoxy .propylamine, 3-ethoxy propylamine, 3-(2-ethy1- .hexyloxy) propylamine, B-isopropoxy propylamine, B-methoxy ipropylamine, 3-methoxyethoxy propylamine, 3-octadecy1oxy propylamine,

.3-propoxy propylamine, 3-isoamoxy cyclohexyl amine, -4-.isoamoxy cyclohexylamine, 2,2-dithio- .bisethylamine, 'o-aminoephenyl mercaptan, 2-- =aminoe4-chloropheny1 mercaptan, .1,'1-dichloro methyl "amine, 2-chlorobutylamin'e, 2-chloroprogpylamine, .3-chloro-propylamine, alpha-bromobutylamine, beta-bromobutylamine, 3-bromolcyclohexylamine, -4 bromo-cyclohexylamine, 2- iodo cyclohexylamine, monoethanolamine, 2- e-aminocyclohexanol, '2- 'aminoi methyl jcyclohexanol, ii-amino 'octanol,

E '5-amino 2,7-dimethyl 14 octanol, beta-amino ethyl mercaptan, o-aminobenzene sulfonic acid, 3-amino-2-hydroxy propane sulfonic acid,'naph- .thionic,acid,.nitro.anilines, nitro naphthylamines, -nitro-phenylene .diamine, znitrotoluidines, .gly- .cine, anthranillic acid, amino benzoic .acid,

ametanilic acid, ethylene diamine, :Dhenylenediamine, 1,2-propanediamine, and i3',3-diphenyldiamine.

Many of the 2-imino- 4-thiaz olines and their acid salts obtainable by the reaction of this invention are new compounds which find utility as accelerators and activators in "the vulcanization of rubber and 'as intermediates for the synthesis of other rubber chemicals, as medicinals and medicinal intermediates, .as agricultural chemicals with insecticidal, ifungicidal, and herbicidal properties and ifor-various other purposes.

One class of novel .2eimino-4-thiazolines 02 special utility Fin the :rubber industry are those which'possesstheistructure R1-o-'N-Ra c=Nn Rr-CS wherein. Riand R2 represents hydrogen .oralkyl, Re :represents alkyl or and and the totalnumberbfcarbon atoms in the R groupsis atleast 3, .and theiracidsalts. Compounds of this type are-useful in synthesizingv accelerators of vulcanization and are themselves accelerators, being particularly valuable accelerators when .Rz .is a-ryl. .If .R3 .is a .hydroxy. carboxy, v.mercapto, amino .or .sulfonic :acid substituted 'alkyl .or.aryl radical theaccelerator is. modified inits activity. For example, compounds wherein R3 is acidic, as in the case where itv contains acarboxyorsulionic-acid group, are ,possessed .of delayed.action by reasonof theacidic group whereas compounds whereinRs" containsan amino or mercapto group possess their own activatingegroupandare 10011- sequently faster in their activity.

The followin specific'examples will more fully describe the method of preparing'theZ-imino-B- substituted-l-thiazoline compounds of this invention. Throughout the examples the lterm parts isemployed to indicate parts :by'weigh-t.

EXAMPLE I 25.8 parts of a mixturetof thiocyano butanones prepared by the reaction of sodium thiocyanate "with a mixture containing 3-chloro-butanone-2 and 1-chloro-butanone-2 resulting from the chlorination of one mole of methyl-ethyl ketone with one moleof chlorine, con'taining 85% byweight of B-thiocyano-butanone-Z and 15% by weight of l-thiocyano-butanone-Z were added to a-benzene solution containingv 26 parts of aniline hydrochloride and 87 parts of "benzene. in a reactor :jfitted with a:stirren:anzesterification headzand a thermometer for measuring the temperature in'the reaction zone. .This .mixture was stirred and heated to about,80-.C. The reacting mixture was maintained at C. until3.6 parts of water had been azeotropically removed, about 3 hours. When no further water-benzene azeotropic mixture appeared in'the reflux, the mixture resulting from this reaction was cooled to 20 C., Withdrawn from the reactor and filtered to recover the precipitate formed during'the reaction. The precipitatedproduct was washed once with benzene, twice with acetone, and then dried. In this 'manner'46.1--parts, a9g6% yield, of a solid'material melting at 220 to '225 C. were recovered. Thismixture contained 39.2'parts; 2=imino- 3-phenyl-4-,5-dimethyl- 4 -thiazoline hydrochloride and 6.9 parts, 15%, 2-imino-3-phenyl- 4- ethyl-e-thiazoline hydrochloride.

EXAMPLE II A solution containing 26 parts of 'an'iline hydrochloride dissolved .in '79 parts 'of'benzene and :8 partsroftn-butanol, and 25.8 parts of the'mix- *ture :of 'ithiocyan'o :butanones described :in Ex- :ample; I'were placediin azreactor-of the type used .;1n:E-xample I. This mixture Was 'heatedat 80 C.

.- until 3.6 .:parts of :water had been 'azeotropicaHy 'removedsfrom theireaction. The-resulting mix- -.t111.e was ocooled to room temperature, removed "from :the reactor and filtered to recover the-precipitate which ihadfiformed during the reaction. .ThlS precipitate 'was washed once with benzene,

: "twice cwithiacetoneia'nd'then dried. in this man- -,;;ner there was obtained 37.1 parts-of a -mixture the molecular formula of C11H13N2SC1.

compounds consisting of 85% 2-imino-3-phenyl- 4,5-dimethyl-4-thiazoline hydrochloride and 15% 2-imino-3-phenyl 4-ethyl 4-thiazoline hydrochloride. The mixture had a melting point of 220 C. to 225 C.

EXAMPLE III There were reacted 26 parts of aniline hydrochloride and 25.8 parts of the mixture of thiccyanobutanones described in Example I in the presence of 44 parts benzene and 34 parts of heptane as a reaction diluent at about 90 C. until 3.6 parts of water were azeotropically removed. The resulting mixture was cooled to room temperature and filtered to recover the precipitate which formed during the reaction. The precipitate was washed once with benzene and twice with acetone and then dried. In this manner 43.? parts of a mixture of 2-imino-3- phenyl-4-thiazoline hydrochlorides containing 85% 2-imino-3-phenyl-4,5-dimethyl-4-thiazoline hydrochloride and 15% 2-imino-3-phenyl-4-ethyl-4-thiazoline hydrochloride, were obtained.

EXAMPLE IV There was reacted in the presence of '79 parts of benzene and 8 parts of n-butanol at 80 C., 26 parts of aniline hydrochloride and 25.8 parts of 3-thiocyano-butanone-2 until 3.6 parts of water were azeotropically removed. The resulting mixture was cooled to room temperature and filtered to recover the precipitate which had formed during the reaction, This precipitate was washed once with benzene and twice with acetone and then dried. In this manner 41 parts, an 80% yield, of this precipitate were recovered. This material had a melting point of 225 to 243 C. A sample of this product was purified by recrystallizing from ethanol. The purified material had a melting point of 239 C. to 241 C. A sample of the purified material was analyzed for its chemical composition and was found to contain: 7

Composition gs gg y for Analysis Percent g gfi C, 54.90 C, 55. H, 5. 46 H, 5. 40 N, 11. 64 N, 11. 60 S, 13. 29 S, 13.30 C], 14. 77 c], 14. 70

The chemical analysis is in agreement with the calculated composition for a compound having A portion of the compound prepared in this example was neutralized with aqueous sodium hydroxide which precipitated an aqueous insoluble material, the free base of the compound prepared in this example. This free base together with other compounds of the same empirical formula such as 2-anilino-4,5-dimethylthiazole, 2-thiono-3- phenyl-4,5-dimethyl thiazoline, 2.-amino-4,5-dimethylthiazole, and 2-mercapto-4,5-dimethyl thiazole were subjected to ultra-violet analysis. The absorption curves for these other compounds were distinctly different from that of the free base of the compound prepared above, although certain similarities were noted. For example, the absorption peaks of 2-mercapto-4,5-dimethyl thiazole and 2-thiono-3-phenyl-4,5-dimethylthiazoline occurred at the same wave lengths whereas 2-amino4,5-dimethylthiazole and the free base prepared above had absorption peaks atthe, same wave lengths. 2-thiono-3-phenyl- 4,5-dimethylthiazoline and this free base'both had lower maximum absorption peaks which in the case of the 2-thionothiazoline was due to the presence of the phenyl group in the 3 position. But the curves of the free base and z-anilino- 4,5-dimethylthiazole had no points of similarity.

The ultra-violet analysis is convincing proof that the compounds prepared in this example were 2-imino-3-phenyl-4,5-dimethyl-4-thiazoline hydrochloride and its free base which is 2-imino- 3-phenyl-4,5-dimethyl-4-thiazoline. The free base, 2-imino-3-phenyl 4,5-dimethyl-4-thiazoline, is a crystalline solid whose melting point is 52 to 53 C. The ultra-violet absorption spectra of the compound shows an absorption peak of 261 A at Emax of 33.5.

EXAMPLE V 26 parts of 3-thiocyano-butanone-2 and 25.8 parts of aniline hydrochloride were heated together at C. for 4 hours in a reactor open to the atmosphere. A solid product was formed. This product was dissolved in a mixture of benzene and ether, the ether was driven off and a solid crystalline material precipitated which was dried. In this manner 24 parts of 2-imino-3-phenyl- 4,5-dimethyl-4-thiazoline hydrochloride having a melting point of 239 to 242 C. were obtained.

The following example illustrates the reaction of a thiocyano carbonyl compound of the class hereinbefore described, with a free primary amine in such a manner that a 2-amino-thiazole is recovered by distillation of the resultin reaction mixture, the aminothiazole resulting from EXAIVIPLE VI One mole (93 parts) of aniline, 2.8 parts of aniline hydrochloride, one-half mole (64.5 parts) of 3-thiocyano-butanone, and 175 parts of benzene were added to a. reactor of the type hereinbefore employed. This mixture was heated to about 00 C. for 3 hours until all the water formed during the reaction, 8.5 parts, was azeotropically removed with the benzene. The excess benzene and unreacted aniline were then removed by distillation at a reduced pressure produced by a water aspirator. The remaining residue was distilled at a pressure of 0.1 to 0.4 mm. Hg absolute. 72 parts of a white crystalline product melting at 101 to 105 C. were thus recovered by distillation and the residue was a resinous tar. The white crystalline product recovered by distillation was purified by first recrystallizing from a mixture of ethanol and benzene and then from ethanol. The purified product was a colorless crystalhne material having a diamond shape and melting at 107 to 1095 C. By ultra-violet absorption data this material was identified as 2-anilino-4,5-dimethylthiazole. The following chemical analysis for the purified 'ompound agrees with that calculated for 2-anilino-4 5-dimethlythiazole.

Chemical Analysis Pereen Percent positi on sltion for the abov I lculat p epared fig- 23 3 Products zole 64 64. 67 5. 91 H, 92 67 N 13. 71 15. 71 s, 15. 69

i mass.

9 EXAMPLES VII TQa'XIII In the above-Examples I to V, thereactants were employed in'substantially -the-same propor- Also 7 the reaction temperature employedwas'80" C. wherethereaction was carried'out in tions.

2-imino-3epheny1-4,5Fdimethylr4- thiazoline hy.-. and 2-imino-3-phenyl-4rdrochloride (85 ethyl-4-thiazoline.hydrochlorides A mix-*- ture'of thefree bases of these iminohydrochlo- V rides can be'easily 'recovered'by neutralizinggthe. hydrochlorides with. sodium hydroxide; for: the

free; basesare. insoluble in water; andv can.

recoveredini any suitable manner;

The following: Examples XV to. illustrate the use of various-reactants.other than those of the precedingexamples with formation of corresponding different.compounds.v

Table I gg fgg Reaction Conditions f gg f" Phenyl-4*5- Exfilgple 11 Th 7 W t ethyl?! An me 3- iocy- Reaction Tam a er iazoline Hydros and-.Buta- Azeotropic-Solvent- 'Remov- Hydrochlor chloride none-2 Tune 00 ed, Parts .ide Percent.

11. 2 6.45 none"-.. 2 90. i 20. 0 77. 6 64. 5 175 parts benzene 3. 3 106 8;? 7B. 0' 64. 8 64:5" '175 parts benzene and parts n-butanol 4. 25 84 8.8 78. 2 64.8 64:5 do 5.15 85 8.6 I 83;7'. 66.1 64.15 i. 194 partsbenzene n-butan 3.0.- 82 5 8314- 89:5 XII; 131 129 345-parts benzene n-butano 3525 85" 18. 4 75. 0- XIII 131 129 390 parts benzene and'40 parts n-butanol; 4.0 81' i 18' I 81. 6

'Notmeasnred:

The followingExample; XIV illustrates theb'est. EX 5. MPI E practices in' carrying outthe process; of preparing. 2.-imino-4-thiazo1ine compounds according to;

thisinvention .and;also:illustrates a further 'modirfication. of. the process. of this; invention. Alfthoughthe process is :described' in detail in-JJhis" example employing: aniline; hydrochloride and. av mixture of thiocyano butanones' (85%. .3.-thio.- cyano-butanone-Z and.15.% l-thiocyano butanone-2.) asreactants,.the conditions and process" steps described: are; applicable for: any combination' of." reactants and; in. general, will produce.

thezbest. results.

EXAMIPLE XIV" A mixture consisting. of"1.8;1.parts of benzene, 0.67 parts of n-b-utanol (aratio of. 27 parts of benzene for each part" ofbutanol') 2187parts of. aniline hydrochloride, 2.43ipartslof3=thiocyano butanone Z and 0:43; parts of l-thiocyano-butanone-2:. in a reaction. vessel having aheating; jacket. 2. stirrer and an esterification head; was stirredand heated to 80 C. This temperature was maintained until 0.4 part'of water. was'azeotropically removed; this requiring aboutfiiB hours; Thenthe heating was discontinued and the re.-

sulting slurry" Was extracted with 13: parts of? water. After the water extraction the benzene, and Water layers were separated andv the benzene layer was extractediwith water again, After the. benzene layer had been extracted three times equal quantities of water were. employed for each extraction, the benzene was distill'ed'and stored for further use. All three water extracts were combined and the butanol was removed by dis-.- tillation as a water azeotrope. A sample of the. aqueous solution remaining in the still pot was. found to contain 13.83% of'the alkyl 2-imino-4- chloride, formed. during. this. reaction were,

Employing the procedure of Example L t-here wasreacted 67 parts of' tmethyla'mine hydrochloride; 129 a parts: of? 3+thiocyano-butanone-2-= in the" The resultingmixture was cooled to roomtem' perature and. filteredto recover the precipitated material which formed during thereaction'. The recovered 1 solid material was washed once with benzene and twice-with, acetone and then dried. In this manner 153 parts, an 86% yield, of 2- imino-3,4,5-trimethyl-4-thiazoline hydrochloride were obtained; This material after being purified by recrystallization fromethanol had a melting point of 282 to. 283 C. By chemical analysis 'this compoundwas found to possess the following composition. which is in agreement with the calculated chemical compositionof the Z-imino- 3,4,5-trimethy1 4 thiazoline hydrochloride.

Asolution containing ..64.5 parts.ofi'3 thiocyanobutanone.-.2, 41 partsof .ethylami'ne hydrochloride, 261 partsofbenzene and .20v parts-of" n-butanol;

was stirred and refluxed until"9i parts of water. were azeotropically removed.v The. resulting; mix-' ture was cooled. t'o.ro.om. temperature. and filtered; to recover the precipitate. which. formed during.

the reaction. In this manner .82.5,-.parts,.an..86%fl yield, of J dry solidimaterial' was. recovered. This.

Chemical Composition By Analysis, Calculated,

Percent Percent C, 43.53 C, 43.67 H, 6.76 H, 6.75

N,.14.62 N, 14.54 S 16.72 S, 16.64

The compound prepared above when neutralized with a basic material such as sodium hydroxide, potassium hydroxide or calcium hydroxide forms the free base, 2-imino-3-ethyl-4,5- dimethyl-4-thiazoline.

EXAMPLEXVII 25.8 parts of 3-thiocyanobutanone-2 and 38 parts of 5-amino-salicylic acid hydrochloride were suspended in a mixture containing 183 parts of benzene and 40 parts of n-butanol and then heated for 6 hours at 78 to 80 C. while the water formed during the reaction was azeotropically removed. The resulting mixture was cooled and filtered to recover the grey crystalline material which formed during the reaction. The crystalline product was washed with a mixture of benzene and hexane and then recrystallized from ethanol to purify. In this manner 54 parts of a white crystalline material melting at 279 to 281 C. were recovered. A portion of this material was analyzed and was found to have the following chemical composition which agrees with that calculated for 2-imino-3-(3-carboxy-4-hydroxyphenyl) -4,5-dimethyl-4-thiazoline hydro chloride.

Chemical Composition By Analysis, Calculated, Percent Percent E, 4.41 H, 4.36 C, 48.13 C, 47.92 N, 9.33 N, 9.32 S, 0.63 S, 10.66 01, 11.70 01, 11.78 0, 15.80 (by difler- O, 15.96

once) 32.3 parts of 3-thiocyano-butanone-2 and 33.9 parts of cyclohexylamine hydrochloride were suspended in a mixture consisting of 7 parts of nbutanol and 183 parts of toluene in reaction equipment described in Example I. The suspension was heated at 106 C. for about 7 hours while about four parts of water were azeotropically removed. The slurry remaining in the reactorwas cooled and filtered to recover the crystalline product formed. The crude crystalline product was taken up in hot ethanol and purified by recrystallizing. This purified product had a melting point of 243 to 245 C. A portion of the product was analyzed for chemical composition 12 and another portion was submitted for ultraviolet spectra analysis. The chemical analysis for the above ethanol purified product together with the chemical composition calculated for 2-imino- 3-cyclohexyl 4,5-dimethyl-4-thiazoline hydrochloride are given below.

Chemical Composition By Analysis, Calculated,

Percent Percent C, 53.53 C, 53.53 H, 7.78 H, 7.76 N, 11.39 N, 11.35 S, 12.98 B, 12.99 01, 14.40 01, 14.37

The close agreement between the chemical composition by analysis with that calculated together with the ultra-violet spectra analysis clearly showed that the final product obtained was 2- imino-3-cyclohexyl-4,5-dimethyl 4 thiazoline hydrochloride.

EXAMPLEXIX To a reactor as described in Example I there was added 32.3 parts of 3-thiocyanobutanone-2, 24.4 parts of monoethanolamine hydrochloride, 183 parts of benzene and 70 parts of n-butanol. This mixture was heated at 79 C. for 20 hours while about five parts of water were azeotropically removed. The resulting slurry wa cooled, filtered, dried and the crystalline product was washed with acetone. A yield of 48 parts of crude product, about 92%, was thus recovered. The crude crystals were dissolved in hot ethanol and recrystallized after concentrating by evaporation of some of the ethanol. The purified product was a white crystalline material melting at 199 to 200 C. The chemical composition of this product as determined by analysis was found to be 40.25% carbon, 6.35% hydrogen, 13.4% nitrogen, 17.02% chlorine, and 7.62% (by difference) oxygen. The chemical analysis together with the ultra-violet spectra analysis showed conclusively that the compound prepared was 2-imino-3-(beta-hydroxyethyl) -4,5-dimethyl 4 thiazoline hydrochloride.

' EXAMPLE XX 3-(beta-chloroethyl) -2-imino 4,5-dimethyl-4- thiazoline hydrochloride was prepared by reacting 64.5 parts of 3-thiocyanobutanone-2 and 58 parts of beta-chloroethylamine hydrochloride in the presence of 137 parts of benzene and 32 parts of n-butanol at C. until about 9 parts of water were azeotropically removed, about 5 hours. The resulting slurry was filtered, washed with benzene and acetone and dried. In this manner 112.5 parts, a 99% yield, of a crude product melting at 184 to 203 C. was recovered. The crude product after purification from ethanol was a white crystalline material melting at 207 to 211 C. Chemical analysis of this compound, in table below, and ultra-violet spectra analysis showed that desired compound was obtained.

s 14 by reacting 32.3 parts of 3-thiocyanobutemone-2:- dried-2' I'i'rtlii's nianner 59.2 parts, a 93% yield and 36.4 parts ofo-aminophenol hydrochloride of the crude compound melting at 219 to 232 C. in the presence of 183 parts of benzene and 32 was obtained. parts of butanol at 75 to 79 C. until 4.5 parts In the following examples; thedetails of the of water were azeotropically removed, about 5 preparation foreachmompound has been omitted. 2 hours. The resulting slurry was, filtered, and Insteadthereis-tabulatedthe reactants necessary the solid product was Washed with, acetone and to produce each compound.

EXAMPLES XXIITO XLIII- Reactants g g gg I Product AmineHydrohalidm 'lhlocyano Carbonyl XXII... Aniline hydrochioride..-....... ithiocyanoacetaidehyde HCL-NEO.

- G=NH.HCI

2-imluo-3-phenyi-4-thiazoline hydrochloride GHQ-CH! C a CH| XXIII Cyclohexy} amine hydrobro- -..-.do. HC-N/ CHmCI I;

C=NH.HB1'

2-imino-3-cyc1ohexy1-4'thiazoline hydrobroniide XXIV-. Ethyiamine hydroch1oridedo HC-N-CgH;

C=NH.HC1

2-imino-3-ethy1-4-thiazoline hydrochloride XXV"--. Beta-amino methylpropionate 3-i;hiocyano-butenone-Z. CHr-C-N-CHQCHaCOOCHl hydrochloride.

C=NH.HCI

CHa -S 2-imino-3(bcta-carbomethoxy-ethyi)-4,5- dimethylei-thiazoline lsigdg chloride 34H1 XXVL... n-butyiamlne hydrobronnde CHCHg H HO N SI C N \G=NH.HBI'

.Alpharthiocyauo propionaldeh yde CHr-C-S Z-imino-3-n-butyi-5-methy1-4-thiazo1ine hydrobromide XXVII... isopropyiamine hydroiodide-.. CHQHPCHCHO I I CH,'CH|

CH: SON HI H C-N I C=NH.HI

24sopropyl-2-thiocyauo acetaldehyde Zdmino-IfiMillsopropyl 'i thiazolinehydroiodlda xxvnnaniline hydrochloride O-onono HCN\ soN C=NH.HO1

II 2-pheny1-2-thiocyano acetaldehyde O-C- S 2-imino-3;5 diphenyl-l-thiazoline hydrochloride XXIX tmethylamine hydrochloride... 7 -OBOHO: H0

s ON

2-phenyi-2-thiocyano acetaidehydo l 2-imino-3-methyi-5-phenyl-4-thiaioline hydrochloride EXAMPLES XXII T XLIII-Continued Reactauts. Example Product Number Amine Hydrohalide Thiocyano Carbonyl H H(I1=C\ HC=C-O XXXIXLQ 2-furanamine hydrochloride-.. 3'-thiocyano-butanone-2 CH;--G-N C'=N'HHCL CHr- -S 2-imlno-3-(2-fursn)-4,5-dimethyl-4-thlezollne I hydrochloride XL p-nitro aniline hydrochloride ...-do CH;CN

' C=NH.HG1

OH;OS

2-imino3-(p-nltrophenyl)-4,5 dimethy1-4- thiezoline hydrochloride- CHgCHgCHI XLI 3-methoxy propylsmine do hydrochloride. CHr--C-N 0 CH1 C=NH.HCl

CHr- :-S

amino-3-(methoxypropyl)-4,5-dimethyl-4- thiazoline hydrochloride SH l XLII c-amino phenyl mercaptan ...-do CHr-C-N hydrochloride.

C=NH.HCl

CH:- -S

* 2-imlno-3-(o-mercspto phenyl)-4;5-dimethyli-thlazoline hydrochloride BOuH XLIIIL... o-amino benzene'sull'onic acid .-.--d0. CH|-C-N hydrochloride.

C=NH.HC1:

CHI-- --8 2-l1 nino-3-(o-benzene-sullonic-acid)-4,5- dimethyl-ll-thiazoline hydrochloride Any of the 2-imino-4-thiazoline hydrohalide products illustrated in Examples XXII to XLIII can be neutralized with a basic material such as sodium hydroxide, to the free imino base.

In all the illustrative examples an amine hydrohalide was employed as a reactant with the subsequent formation of a 2-imino-4-thiazo1ine hydrohalide which on neutralization yields the correspondingiree base. But, as hereinbefore stated, a primary amine may be employed as a reactant with the thiocyanocarbonyl compound. Where a primary amine is employed as a'reactant, it will be found that the yield of the Z-imino- 4-thiazoline products will be substantially lower than that reported in the specific examples, in the nature of to 40% of the theoretical yield.

As hereinbefore stated, the '2-imino-4-thiazoline compounds can be readily converted to 2- amino thiazoles. The following example illustrates the conversion of 2-imino-3-phenyl-4,5- dimethyl-4-thiazoline to 2-anilino-4,5-dimethylthiazole.

EXAIVIPLE XLIV Twenty-four parts of 2-imino-3-phenyl-4'j di-methyl--thia'zoline hydrochloride prepared in Example IV were added to parts of hydrochloric acid (20% HCl). This mixture was boiled for 30 hours with periodic replacement of the water evaporated and, upon cooling, there was recovered 17 parts, a '7 1% yield of Z-anilino- 1,5-dimethylthiazole hydrochloride melting at C. to 118 C. This material was added to a- 5% aqueous sodium hydroxide solution and the precipitate which formed was recovered and recrystallized. This purified material had a melting point of'100-.5 C. to 107.5 C. and when mixed with an authentic sample of 2-anilino-4,5- dimethylthiazole caused no depression in the melting, point of the authentic amino thiazole. Hence the final product obtained by the neutralization step was 2-anilino-4,5-dimethylthiazole.

Other chemical uses of the 2-imino-4-thiazolines as intermediates in organic synthesesare illustrated by the following examples;

2,4 dinitrochlorobenzene.

19 EXAMPLE XLV" 2-(2,4-dinitrophenyl imino) -3-phenyl-4,5-dimethyl-4-thiazoline was prepared by reacting 2-imino-3-phenyl-4,5-dimethyl-4-thiazoline with This reaction was carried out by adding 10.2 parts of 2-imino-3- phenyl-4,5-dimethyl-4-thiazoline hydrochloride, 2 parts of sodium hydroxide, 40 parts of ethanol, and 10.2 parts of 2,4-dinitrochlorobenzene to a reactor, the free 2-iminothiazoline being formed in situ. This mixture was heated for about minutes at 70 to 75 C. A very vigorous reaction occurred giving a blood red solution with a white precipitate (NaCl), some of the reactants were lost due to the vigorous nature of the reaction. The resulting hot mixture was filtered to remove the NaCl and after cooling the ethanol solution, a red-brown precipitate formed. This precipitate was separated into two diflerent crystalline components by repeated recrystallization from an ether-hexane mixture.

One product was a light yellow crystalline material having a melting point of 85 to 855 C. after chromatigraphic purification. Chemical analysis showed that this material contained no sulfur but had .81% hydrogen, 45.42% carbon, 13.28% nitrogen, and 37.49% oxygen (by difference). The chemical composition agrees with that calculated for 2,4-dinitrophenetole (the product of the reaction of ethanol with the dinitrobenzene chloride) which has a melting point of 85 C. as reported in the literature.

The second component isolated was a bright red crystalline solid and had a melting point of 171.5 to 174 C. The chemical composition of this solid material was found by analysis to be 3.83% H, 55.25% C, 15.17% N, 8.57% S, and 17.18% 0 (by difference). The chemical analysis and the red color which is characteristic for compounds containing the structure C-N u C-S N02 establishes that .the red component isolated was the desired product.

EXAMPLE XLVI 12 parts of 2-imino-3-phenyl-4,5-dimethyl-4- thiazoline hydrochloride were dissolved in 63 parts of glacial acetic acid. To this solution there was slowly added 4.5 parts of sodium nitrite dissolved in parts of water over a period of about minutes while maintaining the reaction at about 25 C. Orange crystals precipitated from the reaction mixture. The resulting mixture was poured into twice its volume of ice and, after the ice had melted, the solid product was recovered by filtration and then dried. There was recovered 10.9 parts of the desired product, a 95% yield, which had a melting point of 149.5 to 1505 C. This product was 2-(N-nitrosoimino) -3-phenyl-4,5-dimethyl-4-thiazoline.

EXAMPLE XLVII Benzoyl chloride when reacted with 2-imino- 3-phenyl-4,5-dimethyl-4-thiazoline (formed in situ by neutralizing its hydrochloride with sodium hydroxide) in the Schotten-Bauman reaction gave a high yield of a white crystalline material having a melting point of 172-174.5 C. This material was found to be 2-(benzoyl imino) 3-phenyl-4,5-dimethyl-4-thiazoline.

Another property of the 2-imino thiazoline-4 compounds hereinbefore disclosed was the ability of these compounds to accelerate the vulcanization of rubbery materials. The following example illustrates this property.

EXAMPLE XLVIJI There was thoroughly mixed together parts of a rubbery material obtained from the copolymerization of butadiene-1,3 with styrene in an aqueous medium containing a salt of disproportionated abietic acid (known as a rosin soap) as the emulsifying agent, said rubbery material being known as GR-S-lO; 40 parts of carbon black; 1.5 parts of stearic acid; 2.0 parts of sulfur; and 2.2 parts of 2-imino-3-phenyl-4,5-dimethyl-4-thiazoline. Portions of this mixture were heated in a press at 300 F. for varying periods of time, after which stress-strain tests were made on the vulcanizates so prepared. In the following table are the physical properties so obtained.

Synthetic rubberVulcanized at 300 F.

300 Ultimate M o dulm Tensile Percent Time, Min. lbs strength, Elongation lbs. per at Break sq. m.

1 Too low to measure.

EXAMPLE XLIX There were thoroughly mixed together 100 parts of natural crude rubber, 50 parts of carbon black, 5.0 parts of zinc oxide, 3.0 parts of stearic acid, 1.0 part of phenyl-beta-naphthylamine, 3.0 parts of sulfur, and 1.0 part of 2-imino-3-phenyl- 4,5-dimethyl-4-thiazo1ine. Portions of this mixture were heated in a press at 280 F. for varying periods of time. The data obtained from stressstrain tests made on the resulting vulcanizates are tabulated below:

vulcanization of natural crude rubber at 280 F.

3007 Ultimate I Modufus Tensile Percent Time, Mm. not Strength, Elongation i lbs. per at Break sq. in.

EXAMPLE L There were thoroughly mixed together 100 parts of natural crude rubber, 50 parts of carbon 'black, 5.0 parts of zinc oxide, 3.0 parts of stearic acid, 1.0 part of phenyl-beta-naphthylamine, 3.0 parts of sulfur and 1.0 part of 2-imino-3-phenyl 4,5-dimethyl-4-thiazoline. To portions of this composition there was added various mercapto compounds to determine what mercapto compounds activate the accelerating properties of the 2-imino-4-thiazoline compounds. The activation of the above 2-imino-4-thiazoline compound was determined by a Mooney viscometer at 250 F. with the small (1 inch) rotor and the results of these tests are tabulated below where scorch time is the time in minutes for the sample to reach a minimum viscosity plus the time for ass-sea Activation of 2-imino-4-thiazoline accelerators I P'aftspet Scorch Cure I Cure Mercapto Activator Time Time Rate 4.7 8.4 3:7 0.2 5. 9 10.2 4.3 0.4 7. l2. 1 5. 1 Betamercapto propionic acid.. 0.2 5.5 9:? 4:2 S-Mercapto Benzoic Acid 0.2 417 8. 2 3. 5 2 'Mercapto 4,6,6 Trimethyl thiazine 0.2 4. 3 7. 0 3. 7 2-Meroapto-benzothiazole .7 0.2 2. 7 4. l 1.4 '2 .Mercapto 4,6,6 Trimethyl thiazine 1 0.2 7.0 17:0 10. 0 2-Mercaptobenzothiazole 0. 2 6. 7 .10. 5 3. 8

1} Same vulcanizable composition but no Z-iminoi-thiaz- 0 1H6.

The significance of the above data is as follows: The scorch time values indicate whether or not undesirable prevulcanization will occur during mixing and processing of the rubber composition prior to vulcanization, i. e., if the scorch time is below 5 there is :algreat" possibility of scorch or prevulcanization. The scorch time also indicates delayed action acceleration, i. e. where the scorch time is 10 to 15, the accelerating materials are said to be delayed action accelerators. The cure rate indicates whether :or not the composition will vulcanize rapidly or slowly to a desiredoptimum and a cure rate of from 2 to 5 is desirable.

EXAMPLE LI 2-imino-3-phenyl-4,5-dimethyl 4 thiazoline hydrochloride and 2-mercapto benzothiazole each were added as accelerators to a natural crude rubber composition consisting of 100 parts of natural crude rubber, 50 parts of carbon black, 5.0 parts of zinc oxide, 3.0 parts of sulfur, 3.0 parts of stearic acid, and one part of phenyl-beta-naphthylamine. The following data were obtained by a Mooney viscometer at 250 F. using the small rotor.

Comparative Accelerating Ability of 2-imino-4-Thiazo1ine Compounds Cure Accelerator Rate, Mm. Parts per Scorch 100 parts Time, Rubber Min.

2-Imino-3-phenyl-4,5-dimethyl-4- tbiazoline hydrochloride 1.0 6.0 4. 3 2-Mercapto-benzothiazo1e 0. 5 9. 5 3. 4

EXAMPLE LII 22' data indicates the accelerating properties oi -the thiazole-Z-imino-4-thiazoline salt.

Parts per Accelerator parts 9 g y ofRubber 1 e a e Thiazole-Ilriino-4-Thiazoline 0. 5 I 5. 0 2. 0 'Zimate 0. 2 4. 6 0.9 Captax -o. 5 9. 2 2. 7 Sautocure 0. 5 13.4 5.4

From the above it can be seen that the thiazo'leimino-4 -thiazoline salt would bring about a quite rapid vulcanizationand might even cause prevulcanization but not to the same degree as would the zinc dithiocarbamate. Ratherthe "thiazoleimino-l-thiazohne salt-would be as fast an accel erator as Captax.

Although I have illustrated my invention by means of specific examples, I do notthereby-desire or intend to limit myself solelythereto, for as hitherto stated other'equivalent chemical compounds can be employed as reactants 't-o'prepare other specific members of the classof 2-imino-4- thi-azoline compounds herein disclosed andthe precise proportions of reactants also may be varied, if desired, without departing from the spirit and scope of this invention as defined in the appended claims. y

1. The method which comprises preparin a substantially anhydrous reaction mixture containing, as reactants, an enolizable alphathiocyano carbonyl compound and a primary amino compound selected from the class consisting of primary amines nd the acid salts thereof, heating the said mixture thereby to efiect a chemical reaction involving the splitting out of water from the hydroxyl grou of the enol form of the carbonyl compound and one of the hydrogen atoms of the amino group of the amino compound with formation of an intermediate compound in which the nitrogen atom of said amino group is attached to the carbon atom originally present in the carbonyl group of the carbonyl compound, and removing the water of reaction while continuing to heat the reaction mixture whereupon the said intermediate undergoes ring closure by formation of a bond between the said nitrogen atom and the carbon atom of the thiccyano group, with migration of the remaining hydrogen of the amino group to the thiocyano nitrogen atom, to produce a 4-thiazoline ring to which an imino radical is attached in the 2-position.

2. The method which comprises preparing a substantially anhydrous reaction mixture containing, as reactants, an enolizable alpha-thiocyano ketone and an acid salt of a primary amine, heating the said mixture thereby to efiect a chemical reaction involving the splitting out of water from the hydroxyl group of the enol form of the ketone and one of the hydrogen atoms of the amino group of the amine with formation of an intermediate compound in which the nitrogen atom of said amino group is attached to the carbon atom originally present in the keto group of the ketone, and removing the water of reaction while continuing to heat the reaction mixture whereupon the said intermediate undergoes ring closure by formation of a bond between the said nitrogen atom and the carbon atom of the thiocyanogroup, with migration of the remaining hydrogen of the amino group to the thiocyano nitrogen atom, to produce an acid salt of a 2-imino-4-thiazoline.

3. The method which comprises preparing a reaction mixture containing, as reactants, an enolizable alpha-thiocyano carbonyl compound and a primary amine hydrohalide, and an organic reaction diluent which forms an azeotropic mixture with water, and refluxing the said mixture to effect chemical reaction between the said reactants while azeotropically removing the water of reaction thereby to form, as reaction product, a hydrohalide of a 2-imino-4-thiazoline.

4. The method of claim 3 further characterized in that the hydrohalide of a 2-imino-4-thiazoline formed as the reaction product is recovered and neutralized to form the free base.

5. The method of claim 3 further characterized in that the primary amine hydrohalide is the hydrochloride of a primary amine of the structure Ra-NH: wherein R3 is a hydrocarbon radical, the reaction product being the hydrochloride of a. 2-imino-4-thiazoline in which the hydrocarbon radical R3 is attached in the 3-position.

6. The method of claim 5 further characterized in that the alphathiocyano carbonyl compound is an alpha-thiocyano ketone of the structure m- -soN wherein R1 and R2 are hydrocarbon radicals, the

reaction product being the hydrochloride of a 2-imino-4-thiazoline of the structure 24 wherein each or R1, R2 and R3 is a hydrocarbon radical.

7. The method of claim 6 further characterized in that the primary amine hydrochloride is aniline hydrochloride and the thiocyano ketone is an alpha thiocyano butanone.

8. The method of claim 6 further characterized in that the primary amine hydrochloride is an alkyl amine hydrochloride and the thiocyano ketone is an alpha thiocyano butanone.

9. The method which comprises preparing a reaction mixture containing, as reactants, aniline hydrochloride and 3-thiocyano-butanone-2, and as the reaction diluent a mixture containing benzene and butanol, refluxing said reaction mixture to effect chemical reaction between said reactants while azeotropically removing all of the water of reaction, extracting the resulting benzene slurry with water, and azeotropically distilling of! the butanol, the reaction product 2-imino-3- phenyl-4, 5-dimethyl-4-thiazoline hydrochloride being obtained in an aqueous solution.

JAMES T. GREGORY.

REFERENCES CITED The following references are of record in the file of this patent:

FOREIGN PATENTS Country Date Switzerland Nov. 16, 1945 OTHER REFERENCES Number 

1. THE METHOD WHICH COMPRISES PREPARING A SUBSTANTIALLY ANHYDROUS REACTION MIXTURE CONTAINING, AS REACTANTS, AN ENOLIZABLE ALPHATHIOCYANO CARBONYL COMPOUND AND A PRIMARY AMINO COMPOUND SELECTED FROM THE CLASS CONSISTING OF PRIMARY AMINES AND THE ACID SALTS THEREOF, HEATING THE SAID MIXTURE THEREBY TO EFFECT A CHEMICAL REACTION INVOLVING THE SPLITTING OUT OF WATER FROM THE HYDROXYL GROUP OF THE ENOL FORM OF THE CARBONYL COMPOUND AND ONE OF THE HYDROGEN ATOMS OF THE AMINO GROUP OF THE AMINO COMPOUND WITH FORMATION OF AN INTERMEDIATE COMPOUND IN WHICH THE NITROGEN ATOM OF SAID AMINO GROUP IS ATTACHED TO THE CARBON ATOM ORIGINALLY PRESENT IN THE CARBONYL GROUP OF THE CARBONYL COMPOUND, AND REMOVING THE WATER OF REACTION WHILE CONTINUING TO HEAT THE REACTION MIXTURE WHEREUPON THE SAID INTERMEDIATE UNDERGOES RING CLOSURE BY FORMATION OF A BOND BETWEEN THE SAID NITROGEN ATOM AND THE CARBON ATOM OF THE THIOCYANO GROUP, WITH MIGRATION OF THE REMAINING HYDROGEN OF THE AMINO GROUP TO THE THIOCYANO NITROGEN ATOM, TO PRODUCE A 4-THIAZOLINE RING TO WHICH AN IMINO RADICAL IS ATTACHED IN THE 2-POSITION. 